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IMM Report Number 21

In conjunction with Foresight Update 43

Self-Replication and Pathways to Molecular Nanotechnology

by J. Storrs Hall, Research Fellow, Institute for Molecular Manufacturing

J. Storrs Hall, PhD
J. Storrs Hall, PhD

The extent of investor interest in nanotechnology has increased recently. Nanotechnology holds out a host of profitable opportunities, but the big bonanza remains a full molecular manufacturing capability as envisioned by Drexler in Nanosystems and elsewhere.

This capability would depend heavily on two aspects of the technology — molecular scale manipulation, specifically positional synthesis; and a self-replicating architecture.

The first part is the subject of most current nanoscience efforts. The second is examined less often, so let us do so now. A self-replicating technology does not necessarily mean a specific self-reproducing machine. It more generally means a set of manufacturing capital equipment which includes as a subset of its output everything that is necessary to make more of (each kind of) itself. Indeed no industrial base could survive without this property for the economy as a whole.

The smaller you can make the basic kernel of your technology that has this property, and the tighter the feedback loops, the less expensive its products will be. The capital doubling times for molecular manufacturing should be on the order of hours, compared to years for current technology. This would decrease the price of its products drastically.

What good does it do us to know this, if we propose to invest in nanotechnology? It means that there are more pathways than one might think. Instead of getting small and then becoming self-replicating, one might consider becoming self-replicating and then getting small. This is implicitly what Feynman described in his scheme of the succession of ever-smaller machine shops.

It’s worth pointing out that Zyvex Corporation appears to be taking an interesting hybrid approach — first going to an intermediate scale (MEMS), then going self-replicating, and then presumably proceeding to molecular scale (Some of this work was presented at the Eighth Foresight Conference — see coverage elsewhere in this issue). More power to them!

If only to delineate what the “other side of the envelope” might look like, though, let’s consider a pure Feynman-style pathway. Essentially we would build a self-replicating system in whatever macro-scale technology we could, and then set it to copying itself recursively, but just a little smaller each time.
This is not as simple as it sounds, or it would have been done long ago. One must have a design that is scale-invariant, or a way to change designs as scaling laws invalidate techniques. One of the advantages of this capability-first/size-second approach is that when scale-affected techniques do give out, you have a broadly capable system you can use to experiment with alternative techniques.

The system must be able to do sensing, handling, and assembly as well as fabrication, since those operations cannot be done by a human operator as at the micro scale.

This means that the system is going to be much more complex than a mere machine shop that can make all of its own parts; it is going to have to be able to make fairly sophisticated robotics. This is a substantial task, but far from impossible. Robots of the requisite capabilities are commercially available today — but they are enormously complex, which would require a hugely complex manufacturing system.

The trick, of course, is to design robots as simply as possible, to reduce the complexity of the system. While we’re at it, we need to pick the techniques we’re using in the knowledge that they have to scale down as far as possible. An example is to build robots that operate by feel instead of vision, even though that may be slower and less efficient at macroscale: at nanoscales, vision won’t work but feel does. Electrostatic motors work at nanoscales but electromagnetic ones don’t. We are expecting to use depositional techniques for fabrication at small scales; use them instead of subtractive ones to start with.

The problem with a machine that tries to build a copy of itself is that all the design tradeoffs that help you make precision parts tend to force you to build parts smaller than the manufacturing machine. One way around this, described in my paper [1], involves a two-phase system which has big fabricators that make small parts, and assembly robots (as in the picture) that put the parts together into fabricators and robots. My paper describes a number of techniques which should simplify design at the molecular scale, but the architecture itself is scale-independent.

proposed assembly robot

So how many steps would it take to get to molecular scale? The first thing to realize is that you have reached molecular scale not when your parts are the size of atoms, but when your tolerances are. A typical fine machining accuracy for most of the twentieth century was a ten-thousandth of an inch (2.5 microns). If we can halve the tolerance at each stage, we are only 12 or so steps from molecular accuracy. If it takes a year for each one… !

Reference:

[1] Hall, J. S. (1999): “Architectural considerations for self-replicating manufacturing systems”, Nanotechnology 10(3) pp. 323-330

—Dr. J. Storrs Hall is an IMM Research Fellow. He can be reached at josh@imm.org.

IMM Reports

Topics in Molecular Manufacturing

No. 62. The Artificial Metabolic Organ: Nanorobotic Nutritional Self-Sufficiency
by Robert A. Freitas Jr. Published September 2025.
No. 61. An Exemplar International APM Treaty Compliance Inspection Program
by Robert A. Freitas Jr. Published July 2025.
No. 60. Molecular Workstation Roadmap II
by Robert A. Freitas Jr. Published May 2025.
No. 59. Molecular Workstation Roadmap I
by Robert A. Freitas Jr. Published May 2025.
No. 58. A Nanofactory Roadmap
by Robert A. Freitas Jr., Ralph C. Merkle. Published May 2025.
No. 57. Zero-Emission Gasoline-Powered Automobiles
by Robert A. Freitas Jr. Published April 2025.
No. 56. Design of a molecular Field Effect Transistor (mFET)
by Ralph C. Merkle, Robert A. Freitas Jr. and Damian G. Allis. Published March 2025.
No. 55. Comprehensive Nanorobotic Cure for Male Erectile Dysfunction
by Robert A. Freitas Jr. Published November 2024.
No. 54. How Much Nanomachinery Can We Have on Earth?
by Robert A. Freitas Jr. Published July 2024.
No. 53. Cell Mills: Nanofactory Manufacture of Biological Components
by Robert A. Freitas Jr. Published June 2024.
No. 52. Hairbots: The Future of Nanorobotic Coiffure
by Robert A. Freitas Jr. Published April 2024.
No. 51. Nanofactory-Based Environmental Remediation: Cleanup of Polluted Oil Sands Tailings Pond Water in Alberta, Canada
by Robert A. Freitas Jr. Published April 2023.
No. 50. Energy Density
by Robert A. Freitas Jr. Published June 2019.
No. 49. New Technologies and Climate Change
by Ralph C. Merkle Published June 2017.
No. 48. The Alzheimer Protocols: A Nanorobotic Cure for Alzheimer’s Disease and Related Neurodegenerative Conditions
by Robert A. Freitas Jr. Published June 2016.
No. 47. The Whiskey Machine: Nanofactory-Based Replication of Fine Spirits and Other Alcohol-Based Beverages
by Robert A. Freitas Jr. Published May 2016.
No. 46. Molecular Mechanical Computing Systems
by Ralph C. Merkle, Robert A. Freitas Jr., Tad Hogg, Thomas E. Moore, Matthew S. Moses, James Ryley Published March 2016.
No. 45. The Nanofactory Solution to Global Climate Change: Atmospheric Carbon Capture
by Robert A. Freitas Jr. Published December 2015.
No. 44. Molecular Space Frames: An Atomically Precise Aerogel
by Ralph C. Merkle Published January 22, 2014.
No. 43. Diamond Trees (Tropostats): A Molecular Manufacturing Based System
for Compositional Atmospheric Homeostasis

by Robert A. Freitas Jr. Published February 10, 2010.
No. 42. Nanomedicine: Will Intracellular Medical Nanorobots Disrupt the Cytoskeleton (Part II)?
by Robert A. Freitas Jr. Published January 15, 2004.
No. 41. Recent results in SRMS
by J. Storrs Hall. Published January 15, 2004.
No. 40. Steps Toward Nanotechnology
by Jim Lewis. Published August 31, 2003.
No. 39. Progress in Thinking Machines
by J. Storrs Hall. Published August 31, 2003.
No. 38. Nanomedicine: Will Intracellular Medical Nanorobots Disrupt the Cytoskeleton (Part I)?
by Robert A. Freitas Jr. Published April 15, 2003.
No. 37. Steps Toward Nanotechnology
by Jim Lewis. Published April 15, 2003.
No. 36. Disasters
by J. Storrs Hall. Published April 15, 2003.
No. 35. Nanomedicine: Is Sapphire Biocompatible With Living Cells?
by Robert A. Freitas Jr. Published November 30, 2002.
No. 34. Steps Toward Nanotechnology
by Jim Lewis. Published November 30, 2002.
No. 33. Nanomedicine: Could Medical Nanorobots Be Carcinogenic?
by Robert A. Freitas Jr. Published August, 2002.
No. 32. Steps Toward Nanotechnology
by Jim Lewis. Published August, 2002.
No. 31. Nanomedicine: The Vasculoid Personal Appliance
by Robert A. Freitas Jr. Published March 31, 2002.
No. 30. Steps Toward Nanotechnology
by Jim Lewis. Published March 31, 2002.
No. 29. Nanomedicine: Volumetric Cellular Intrusiveness of Medical Nanorobots
by Robert A. Freitas Jr. Published December 31, 2001.
No. 28. Nanomedicine: How Nanorobots Can Avoid Phagocytosis by White Cells, Part II
by Robert A. Freitas Jr. Published September 30, 2001.
No. 27. Nanomedicine: How Nanorobots Can Avoid Phagocytosis by White Cells, Part I
by Robert A. Freitas Jr. Published June 30, 2001.
No. 26. Steps Toward Nanotechnology
by Jeffrey Soreff. Published June 30, 2001.
No. 25. Nanomedicine: Microbivores, Artificial Mechanical Phagocytes
by Robert A. Freitas Jr. Published April 1, 2001.
No. 24. Steps Toward Nanotechnology
by Jeffrey Soreff. Published April 1, 2001.
No. 23. Highlights from the Eighth Foresight Conference On Nanotechnology
by Jeffrey Soreff. Published December 30, 2000.
No. 22. Nanomedicine: Nanopyrexia
by Robert A. Freitas Jr. Published December 30, 2000.
No. 21. Self-Replication and Pathways to Molecular Nanotechnology
by J. Storrs Hall. Published December 30, 2000.
No. 20. Nanomedicine: Will Serum Proteins Stick to Nanorobot Surfaces?
by Robert A. Freitas Jr. Published September 30, 2000.
No. 19. Steps Toward Nanotechnology
by Jeffrey Soreff. Published September 30, 2000.
No. 18. Nanomedicine: Clottocytes, Artificial Mechanical Platelets
by Robert A. Freitas Jr. Published June 30, 2000.
No. 17. Steps Toward Nanotechnology
by Jeffrey Soreff. Published June 30, 2000.
No. 16. Diamond in the Sky
by J. Storrs Hall. Published March 31, 2000.
No. 15. Announcing the Opening of the Nanomedicine Art Gallery
by Robert A. Freitas Jr. Published March 31, 2000.
No. 14. Steps Toward Nanotechnology
by Jeffrey Soreff. Published March 31, 2000.
No. 13. Steps Toward Nanotechnology
by Jeffrey Soreff. Published December 30, 1999.
No. 12. Nanomedicine: Is Diamond Biocompatible With Living Cells?
by Robert A. Freitas Jr. Published December 30, 1999.
No. 11. Steps Toward Nanotechnology
by Jeffrey Soreff. Published September 30, 1999.
No. 10. Steps Toward Nanotechnology
by Jeffrey Soreff. Published July 30, 1999.
No. 9. Steps Toward Nanotechnology
by Jeffrey Soreff. Published March 30, 1999.
No. 8. Building Molecular Machine Systems [a preprint]
by K. Eric Drexler. Published January 13, 1999.
No. 7. Reflexive Capabilities
by J. Storrs Hall. Published January 11, 1999.
No. 6. Steps Toward Nanotechnology
by Jeffrey Soreff. Published December 14, 1998.
No. 5. IMM Update: Current Status and Future Directions
by Neil Jacobstein. Published October 21, 1998.
No. 4. Molecular Manufacturing and the Private Aircar
by J. Storrs Hall. Published October 21, 1998.
No. 3. Steps Toward Nanotechnology
by Jeffrey Soreff. Published August 13, 1998.
No. 2. Recent Progress: Steps Toward Nanotechnology
by Jeffrey Soreff. Published July 17, 1998.
No. 1. NIST Holds Microsystems/Nanosystems Meeting
by J. Storrs Hall. Published January 29, 1998.

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